Nuvigil is a wakefulness-promoting agent that works by targeting the hypothalamus region of the brain. It is an enantiopure compound and has a eugeroic effect. In the year 2016, the food and drug administration granted Mylan the rights for the first generic version of cephalon’s Nuvigil to be marketed in the U.S. this medicine is very helpful in treating a condition like Hypersomnia. The nootropic effect of the medicine helps in improving the cognitive senses of the person. They enhance the creativity and memory of the person. It also helps on improving the concentration of the person. The eugeroic property of the medicine keeps the person awake and alert. So if you too want to stay awake and alert then buy Nuvigil online.
KEY INGREDIENTS USED
Nuvigil tablets contain 150 mg of armodafinil. It also contains a few inactive ingredients such as croscarmellose sodium, lactose monohydrate, magnesium stearate, microcrystalline cellulose, povidone, and pregelatinized starch.
HISTORY OF THE MEDICINE
Smart drugs are nootropic and cognitive enhancer that is capable of improving the intellectual capacity of the person suffering from neurological diseases. These smart drugs help students gaining an edge when preparing for exams. The smart drug in ancient times helped the people to work for long hours. They work by increasing the oxygen supply into the brain and therefore stimulating the neurochemicals.
PHARMACODYNAMICS
The medicine has a wake-promoting action that is similar to sympathomimetic agents which include amphetamine (it is a potent central nervous system stimulant that is commonly used to treat attention deficit hyperactivity disorder, obesity, and narcolepsy) and methylphenidate (it is a central nervous system stimulant of phenethylamine and piperidine class that is effective in treating attention deficit hyperactivity disorder). But the pharmacological profile of the medicine does not match the sympathomimetic amines. It is an indirect dopamine receptor agonist, therefore, helps to activate the dopamine receptor. The drug binds in-vitro to the dopamine transporter (DAT) and therefore inhibits the dopamine reuptake. Thus we can say that the activity of Nuvigil is dependent on the dopamine transporter.
KINETICS
The wake inducing the effect of Nuvigil is not antagonized by the dopamine receptor antagonist haloperidol in the mice. Also, the alpha-methyl p tyrosine is an inhibitor of the dopamine synthesis thus blocking the action of amphetamine. But it does not block the locomotor activity that is induced by the medicine. The medicine is also known to produce psychoactive and euphoric effect thus altering the mood and perception of the person.The medicine exhibits a linear time-dependent kinetics. A steady state for the medicine is generally reached within seven days of dosing. When the steady state is reached the systematic exposure for the pill is 1.8 times the exposure observed after a single dosage.
ABSORPTION
The pill is readily absorbed after an oral administration. The oral bioavailability is not yet determined as it is aqueous insoluble. The peak plasma concentration of the medicine is attainted almost after 2 hours in the fasted state. Though food does not completely affect the bioavailability of the medicine, still the time needed to reach the peak concentration may get delayed by three to four hours if taken in a fed state. And since the delay in the Tmax is associated with the elevation of the plasma concentration, therefore, food can affect the onset and time course and action of the medicine.
INTERACTION OF THE MEDICINE WITH OTHER DRUG
Knowing your drug interaction is very important as they can change the way the medicine works and also increases the risk of getting side effects. To know more about the interaction of the medicine with other drug keep a note of all the prescribes, non-prescribed, and herbal products that you use and visit a doctor. Some of the common street drugs that can react with Nuvigil are methamphetamine. Nuvigil may also decrease the effectiveness of hormonal birth control in women. It can affect pills, patches and rings thus increasing the risk of getting pregnant. Therefore discuss with a professional and take the right birth control when taking Nuvigil.
EFFECT OF NUVIGIL WITH MEDICINES
Taking Nuvigil with a few medicines can also raise the heart rate and blood pressure of the person. Also taking drinks with high content can increase the chances of getting a side effect from the medicine. Therefore avoid taking large cups of beverages containing caffeine or eating chocolates that contain caffeine. As this medicine is similar to Modafinil, therefore it is not advisable to take the medicine together. Medications that works by blocking the protein in the body (CYPA4) such as the antifungals (ketoconazole, itraconazole, posaconazole, voriconazole), and a few macrolide antibiotics (clarithromycin, telithromycin). It is important to inform your doctor if you take monoamine oxidase inhibitors such as tranylcypromine (Parnate), phenelzine (Nardil), isocarboxazid (Marplan), selegiline (Eldepryl, Zelapar), and rasagiline (Azilect).
DOSAGE
The recommended dosage of the medicine for people suffering from narcolepsy or obstructive sleep apnea is 150mg. it should be taken once a day and it is best if taken in the morning.
Dosage for shift work disorder- people working in shifts should take the medicine one hour prior to the work. Nuvigil should be taken once in a day. The medicine should be taken in a fixed time. Do not suddenly change the time of intake of the medicine.
FACTS THAT MAKES NUVIGIL BETTER THEN OTHER MEDICINES
- This drug improves the cognitive senses of the person
- It is very effective in enhancing the executive function of the person
- On taking the medicine it will motivate you
- It will enhance the creativity and memory of the patient
- Nuvigil is perfect to improve the concentration of people
- It does not have any withdrawal symptoms and therefore it is not addictive
- Nuvigil can help to kick addiction.
- Taking the pill regularly will help you increase your resistance to fatigue
- Taking Nuvigil helps to improve the mood of the person
- It is very helpful in improving the IQ of the person
- Studies have shown that on taking Nuvigil it helps in reducing the impulse response.
PRECAUTION
- People with an allergic problem should ensure that they are not allergic to the components of the medicine
- if you have a history of heart diseases then it is important to let your doctor about your condition before taking the medicine
- Let your doctor know about all the ongoing medicines of yours.
- People with renal and kidney disorder should talk to a professional consultant before taking the medicine
- If you are an alcohol or a drug addict then inform your doctor about the same.
- If you have a history of mental disorder then talk to a doctor before taking the medicine
- Ensure to regularly monitor your blood pressure while taking the medicine
- If you about to have an surgery even if a dental surgery then let your doctor know about the same
- Pregnancy- in animal studies, taking the medicine when pregnant has shown to form defects in the babies. Therefore it advised to not take the medicine when pregnant. Nuvigil can stop the action of hormonal birth controls.
- Lactation- there is a fair chance that the medicine can cross into human milk thus causing a problem in the nursing child. Therefore you should not take Nuvigil while breastfeeding.
ORAL ADMINISTRATION
- Take Nuvigil by mouth as it is an oral pill
- Taking the medicine with lukewarm water is advisable.
- You can take Nuvigil before or after meal.
- When you are taking Nuvigil, do not take alcoholic beverages with it
- It is very important to check the expiry date of the medicine before consuming the medicine
- Take this medicine once in the morning
- Chewing of Nuvigil is not advisable
- Do not take Nuvigil intravenously in the body
- Never break the pill of Nuvigil
SIDE EFFECT OF NUVIGIL
Nuvigil at times can cause a serious side effect which includes a serious rash or a severe allergic reaction that may affect parts of our body, like the liver or blood cells. It is important to stop taking Nuvigil and visit a doctor when you notice any of the following mentioned symptoms-
- Skin rash
- Hives
- Sores in your mouth
- Dark urine
- Swelling of the face, eyes, lips, and tongue
- Trouble swallowing
- Trouble breathing
- Fever
- Shortness of breath
- Swelling of the leg
- Yellowing of the skin
- Chest pain
- Abnormal heartbeat
Psychiatric symptoms- if you notice any of the symptoms that affect the mental health of the person then it is very important to consult a doctor-
- Anxious feeling
- Depression
- Becoming aggressive
- Excessive talking
- Hallucination
- Mood swings
- Confusion
STORAGE OF NUVIGIL
A proper storage of any medicine is very important to maintain its benefits and shelf life. Some of the facts that should be kept in mind while storing the pills are-
- Do not keep Nuvigil within the reach of children
- Do not place the smart drug in the kitchen or on the shelves in the kitchen as the heat of the stove can alter the composition of the medicine. It can also reduce its shelf life.
- Do not store Nuvigil in direct sunlight.
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